Which of the following mutations is most likely to cause a phenotypic change?

Which of the following mutations is most likely to cause a phenotypic change? 




A) a duplication of all or most introns
B) a large inversion whose ends are each in intergenic regions
C) a nucleotide substitution in an exon coding for a transmembrane domain
D) a single nucleotide deletion in an exon coding for an active site
E) a frameshift mutation one codon away from the 3' end of the nontemplate strand





Answer: D


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